mPharesis™ is the world’s first solution in the treatment of malaria to leverage the magnetic physical properties of the malaria parasite rather than the parasite's biochemical properties—a significant advantage against the parasite's growing resistance to anti-malarial drugs.

By effectively removing the infected red blood cells mPharesis™enables physicians to rapidly reduce the parasites burned and the malaria pathogen, improving the health of the patient.

The use of mPharesis™ in the treatment of malaria episodes is expected to provide the widely documented therapeutic benefits of the exchange transfusion process, while eliminating the exchange transfusion’s risks and prohibitive cost.

Exchange transfusion has been widely applied to the treatment of severe malaria, and it has been often used to treat severe malaria episodes in numerous western hospitals, where screened blood is widely available. However, the risks of infectious disease transmission, immunological complications, the high cost of blood screen procedures, and the limited supply of healthy blood donors have significantly limited and discouraged this procedure in Sub-Saharan Africa. Nevertheless, in these endemic regions up to 70% of all transfusions are performed on malaria-infected children. The World Health Organization estimated that in these regions alone the use of unscreened blood may be the cause of up to 10% of new HIV infections.

By significantly reducing and in most cases eliminating the use of allogenic blood, while delivering the same benefit of an exchange transfusion treatment, mPhareris™ greatly lowers the infectious disease transmission risk, immunological complications, and the overall treatment cost.

THE TECHNOLOGY
mPharesis™ is powered by a proprietary magnetic separation technology developed by Tropical Health Systems and currently refined in collaboration with the Biomedical Engineering Department at Carnegie Mellon University.

The purification process occurs in a continuous and sterile mode, providing a high degree of purification and minimal discomfort for the patient.

The patient’s infected blood is drawn from the blood circulatory system and processed through Tropical Health System’s patent-protected mPharesis™ filter. The cleansed blood is then returned to the circulatory system and the infected red blood cells are disposed of safely. The diagram at top left shows a schematic representation of the mPharesis™ treatment process.